福山大学薬学部


  医薬品化学研究室

  〒729-0292
  広島県福山市学園町1番地三蔵
  TEL:084-936-2111
  FAX:084-936-2024

研究業績

 2000-2005  2006 2007 2008 2009  2010  2011


2018

1

Total Synthesis of Two 8-Oxoprotoberberine Alkaloids: Alangiumkaloids A and B

T. Nishiyama, M. Hironaka, M. Taketomi, E. Taguchi, R. Kotouge, Y. Shigemori, N. Hatae, M. Ishikura, T. Choshi, Eur. J. Org. Chem., 2018, 673-678 (2018). New !

2

Synthesis and cytotoxicity of pyrido[4,3-b]carbazole alkaloids against HCT-116 and HL-60 cells

T. Itoh, N. Hatae, T. Nishiyama, T. Choshi, S. Hibino, T. Yoshimura, M. Ishikura, Med. Chem. Res., 27, 412-419 (2018). New !

3

A dibenzoylmethane derivative inhibits lipopolysaccharide-induced NO production in mouse microglial cell line BV-2

K. Takano, N. Ishida, K. Kawabe, M. Moriyama, S. Hibino, T. Choshi, O. Hori, Y. Nakamura, Neurochemistry International, inpress.

4

Synthesis of N-ω-Phenylalkyl-4-(P-Chlorophenyl)-Piperidin-4-ol Analogues with Potent Antiproliferative Activity Against HCT-116 Cells

N. Hatae, E. Kujime, K. Yano, M. Kizuka, R. Ashida, T. Choshi, T. Nishiyama, C. Okada, T. Iwamoto, T. Yoshimura, Heterocycles, in press.

5

CONCISE SYNTHESIS OF AZAFLUORENONE AND ITS APPLICATION TO INDENO[1,2-c]ISOQUINOLONE

T. Nishiyama, T. Fujiwaki, N. Hatae, E. Uchiyama, N. Takeuchi, K. Minami, C. Yokoyama, T. Kinoshita, M. Ishikura, S. Hibino, T. Choshi , Heterocycles, in press.

 

2017

1

One-pot synthesis of fused 2-pyridones from heteroarylacrylic acid via Curtius rearrangement and microwave-assisted thermal electrocyclization

T. Nishiyama, N. Hatate, K. Hayashi, M. Obata, K. Taninaka, M. Yamane, S. Oda, T. Abe, M. Ishikura, S. Hibino, T. Choshi, Heterocycles, 95, 251-267 (2017). 

2

Synthesis of (±)-Cephalanthrin A Using Baeyer-Villiger Oxidation

T. Itoh, T. Abe, T. Choshi,T. Nishiyama, and M. Ishikura, Heterocycles, 95, 507-516 (2017).

3

Concise Synthesis and Antiproliferative Activity Evaluation of Ellipticine Quinone and its Analogs

T. Nishiyama, N. Hatate, M. Mizutani, T. Yoshimura, T. Kitamura, M. Miyano, M. Fujii, N. Satsuki, M. Ishikura, S. Hibino, and T. Choshi, Eur. J. Med. Chem., 136, 1-13 (2017).

4

Effects of catechins and their related compounds on cellular accumulation and efflux transport of mitoxantrone in Caco-2 cell monolayers

N. Sugihara, N. Kuroda, F. Watanabe, T. Choshi, J. Kamishikiryo, M. Seo, J. Food Science, 82, 1224-1230 (2017).

2016

1

Antioxidant effects of the hydroxy groups in the simple phenolic carbazoles

Y. Hieda, N. Hatae, M. Anraku, N. Matsuura, K. Uemura, S. Hibino, T. Choshi, H. Tomida, O. Hori, and H. Fujioka, Heterocycles, 92, 120-132 (2016).

2

Concise Total Synthesis of Pyrido[4,3-b]carbazole Alkaloids Using Copper-Mediated 6π-Electrocyclization
T. Itoh, T. Abe, T. Choshi, T. Nishiyama, R.Yanada, and , M. Ishikura, Eur. J. Org. Chem., 2290-2299 (2016).

3
A One-pot Synthesis of Phaltanthrin E Through Intermolecular Condensation/Intramolecular Aryl C-H Amination Cascade
T. Itoh, T. Abe, T. Choshi, T. Nishiyama,and , M. Ishikura, Heterocycles, 92, 1132-1136 (2016).
4
Synthesis of Carbazole-1,4-quinons and Evaluation of Thier Antiproliferative Activity against HCT-116 and HL-60 Cells
T. Nishiyama, N. Hatate, T. Yoshimura, S. Takaki, T. Abe, M. Ishikura, S. Hibino, and T. Choshi, Eur. J. Med. Chem., 121, 561-577 (2016).
5
Antiproliferative Activity of Hybrid Compounds Between 6-Methoxy-3-(4-Methoxyphenyl)-1H-Indole and 3-Phenylpiperidine Against HCT-116 and HL-60 Cells
N. Hatae, T. Nishiyama, S. Tamura, R. Yamamoto, A. Matsui, H. Shinchi, S. Hibino, C. Okada, T. Yoshimura, T. Choshi, and E. Toyota, Heterocycles, 93, 440-452 (2016).
6
Total Synthesis of Carbazole-1,4-quinone Alkaloid Koeniginequinones A and B based on a One-Pot Cyclocarbonylation Procedure from 2-Alkenyl-3-iodoindole
T. Nishiyama, N. Satsuki, S. Hibino, M. Fujii, T. Abe, M. Ishikura, and T. Choshi, Heterocycles, 93, 84-100 (2016).

2015

1

NOVEL TOTAL SYNTHESIS OF THE 2-AZAANTHRAQUINONE ALKALOID SCORPINONE USING A TANDEM OXIDATION AND AZAELECTROCYCLIC REACTION

T. Choshi, M. Hironaka, M. Goto, K. Shimizu, Y. Kurata, T. Nishiyama, N. Hatae, and S. Hibino, Heterocycles, 91, 537-549 (2015).

2

Antiproliferative activity of O4-benzo[c]phenanthridine alkaloids against HCT-116 and HL-60 tumor cells
N. Hatae, E. Fujita, S. Shigenobu, S. Shimoyama, Y. Ishihara, Y. Kurata, T. Choshi, T. Nishiyama, C. Okada, S. Hibino, Bioorg. Med. Chem. Lett., 25, 2749-2752 (2015).

3
Simple indole alkaloids and those with a nonrearranged monoterpenoid unit
M. Ishikura, T. Abe, T. Choshi and S. Hibino, Nat. Prod. Rep, 32, 1389-1471 (2015).

2014

1

SYNTHESIS OF 4-ARYLPIPERIDIN-4-OL DERIVATIVES OF LOPERAMIDE AS AGENTS WITH POTENT ANTIPROLIFERATIVE EFFECTS AGAINST HCT-116 AND HL-60 CELLS
N. Hatae, T. Nagayama, H.i Esaki, E. Kujime, M. Minami, M. Ishikura, T.Choshi, S. Hibino, C. Okada, E. Toyota, H. Nagasawa, and T. Iwamura, Heterocycles, 88, 663-673 (2014)

2

TOTAL SYNTHESIS OF THE BENZO[c]PHENANTHRIDINE ALKALOIDS, TERIHANINE AND ISOTERIHANIE, AND THEIR ANTITUMOR ACTIVITY
Y. Kurata, T. Choshi, Y. Ishihara, N. Hatae, T. Nishiyama, and S. Hibino, Heterocycles, 88, 297-308 (2014).

3

The First Total Synthesis of the Antiplasmodial Alkaloid (±)-Cassiarin C Based on a Microwave-Assisted Thermal Azaelectrocyclic Reaction
Y. Tazaki, Y. Tsuchiya, T. Choshi,T. Nishiyama, N. Hatae, H. Nemoto, and S. Hibino, Heterocycles, 89, 427-435 (2014).

4

A Novel One-pot Synthesis of Carbazole-1,4-quinones through Pd-Catalyzed Cyclocarbonylation, Desilylation and Oxidation Processes from 3-Iodo-2-propenylindoles
M. Fujii, T. Nishiyama, T. Choshi, N. Satsuki, T. Fujiwaki, T. Abe, M. Ishikura, and S. Hibino, Tetrahedron, 70, 1805-1810 (2014).
※SYNFACT 2014, 10(4), 353.に紹介されました。

5

Effects of 1,3-di-O-substituted-myo-inositol derivatives on the antiproliferation and caspase-3 activity of HCT-116 and HL-60 cells
N. Hatae, S. Yamauchi, T. Saeki, I. Suzuki, T. Choshi, S. Hibino, C. Okada, M. Hayashi, Y. Watanabe, E. Toyota, Chem. Biol. Lett., 1, 40-43 (2014).

6

Halogen effect on tandem [4+2]cycloaddition/aromatization sequence of allenyl 2-halo-3-vinylcyclohex-2-enyl ether
N. Hatae, I. Suzuki, T. Choshi, S. Hibino, C. Okada, E. Toyota, Tetrahedron Lett., 55, 4146-4148 (2014).

7

N-substituted calothrixin B derivatives inhibited the proliferation of HL-60 promyelocytic leukemia cells
N. Hatae, R. Satoh,H. Chibaa T. Osaki,T. Nishiyama,M. Ishikura, T. Abe,S. Hibino,T. Choshi, C. Okada, E. Toyota, Med. Chem. Res., 23, 4956-4961 (2014).

8
Antioxidant effects of the highly-substituted carbazole alkaloids and their related carbazoles
Y. Hieda, M. Anraku, T. Choshi, H. Tomida, H. Fujioka, N. Hatate, O. Hori, H. Hirose, and S. Hibino, Bioorg. Med. Chem. Lett., 24, 3530-3533 (2014).
9
One-pot synthesis of tryptanthrin by the Dakin oxidation of indole-3-carbaldehyde
T. Abe, T. Itoh, T. Choshi, S. Hibino, N. Ishikura, Tetrahedron Lett., 55, 5268-5270 (2014).

2013

    1. 1
    1. Total Synthesis of the Neuronal Cell-Protecting Carbazole Alkaloids Carbazomadurin A and (S)-(+)-Carbazomadurin B
      Y. Hieda, T. Choshi, H. Fujioka, and S. Hibino, Eur. J. Org. Chem., 2013, 7391-7401.
    1. 2
    1. Effect of the orthoquinone moiety in 9,10-phenanthrenequinone on its ability to induce apoptosis in HCT-116 and HL-60 cells
      N. Hatae, J. Nakamura, T. Okujima, M. Ishikura, T. Abe, S. Hibino, T. Choshi, C. Okada, H. Yamada, H. Uno, E. Toyota, Bioorg. Med. Chem. Lett., 23, 4637-4640 (2013)
    3
    One-Pot Construction of 3,30-Bisindolylmethanes through Bartoli Indole Synthesis
    T. Abe, S. Nakamura, R. Yanada, T. Choshi, S. Hibino, and M. Ishikura, Org. Lett., 15, 3622-3625 (2013).
    1. 4
    1. Modeling Alzheimer's Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness
      T. Kondo, M. Asai, K. Tsukita, Y. Kutoku, Y. Ohsawa, Y. Sunada, K. Imamura, N. Egawa, N. Yahata, K. Okita, K. Takahashi, I. Asaka, T. Aoi, A. Watanabe, K. Watanabe, C. Kadoya, R. Nakano, D. Watanabe, K.Maruyama, O. Hori, S Hibino, T. Choshi, T. Nakahata, H. Hioki, T. Kaneko, M. Naitoh, K. Yoshikawa, S. Yamawaki, S. Suzuki,  R. Hata, S. Ueno, T. Seki, K. Kobayashi, T. Toda, K. Murakami, K. Irie, W. L. Klein, H. Mori, T. Asada, R. Takahashi, N. Iwata, S. Yamanaka, H. Inoue, Cell Stem Cell, 12, 487-496 (2013).
    1. 5
    1. Enantioselective Total Synthesis of 1,3-Disubstituted β-Carboline Alkaloids, (−)-Dichotomine A and (+)-Dichotomide II
      S. Tagawa, T. Choshi, A. Okamoto, T. Nishiyama, S. Watanabe, N. Hatae, M. Ishikura, and S. Hibino, Eur. J. Org. Chem., 2013,1805-1810.
    6
    Simple indole alkaloids and those with a nonrearranged monoterpenoid unit
    M. Ishikura, T. Abe, T. Choshi and S. Hibino, Nat. Prod. Rep., 30, 1-60 (2013).
    1. 7
    1. First Total Syntheses of 1,3-Disubstituted β-Carboline Alkaloids, Dichotomide I and Marinacarbolines A-D
      S. Tagawa, T. Choshi, A. Okamoto, T. Nishiyama, S. Watanabe, N. Hatae, and S. Hibino, Heterocycles, 87, 357-367 (2013).

2012

    1. 1
    1. Influence of Gallate and Pyrogallaol Moieties on the Intestinal Absorption of (−)-Epicatechin and (−) -Epicatechin Gallate
      T. Tagashira, T. Choshi, S. Hibino, J. Kamishikiryou, and N. Sugihara, J. Food Science, 77, 208-215 (2012).
    1. 2
    1. Total synthesis of (±)-Carquinostatin A, and Asymmetric Total Synthesis of (R)-(−)-Carquinostatin A and (S)-(+)-Carquinostatin A
      Y. Hieda, T. Choshi, S.Y. Uchida, H. Fujioka, S. Fujii, and S. Hibino, Chem. Pharm. Bull., 60, 1522-1530 (2012).
    1. 3
    1. Total synthesis of calothrixins A and B by a palladium-catalyzed tandem cyclization/cross-coupling reaction of indolylborate
      T. Abe, T. Ikeda, T. Choshi, S. Hibino, N. Hatae, E. Toyota, R. Yanada and M. Ishikura, Eur. J. Org. Chem., 5018-5027 (2012).
    4
    Synthesis and Antimalarial Activity of Calothrixins A and B, and their N-Alkyl Derivatives
    K. Matsumoto, T. Choshi, M. Hourai, Y. Zamami, K. Sasaki, T. Abe, M. Ishikura, N. Hatae, T. Iwamura, S. Tohyama, J. Nobuhiro, and S. Hibino, Bioorg. Med. Chem. Lett., 22, 4762-4764 (2012).
    1. 5
    1. A Novel Total Synthesis of Isocryptolepine Based on a Microwave-Assisted Tandem Curtius Rearrangement and Aza-Electrocyclic Reaction
      K. Hayashi, T. Choshi, K. Chikaraishi, A. Oda, R. Yoshinaga, N. Hatae, M. Ishikura, and S. Hibino, Tetrahedron, 68, 4274-4279 (2012).
    6
    IMPROVED SYNTHESIS OF THE NEW FURO[3,2-h]ISOQUINOLINE ALKALOIDS TMC-120B AND TMC-120A, AND THEIR INHIBITORY ACTIVITIES AGAINST IFN-γ AND IL-4 PRODUCTION
    T. Choshi, T. Kumemura, H. Fujioka, Y. Hieda, and S. Hibino, Heterocycles, 84, 587-595 (2012).